An integrated metabolomic and proteomic approach for the identification of covalent inhibitors of the main protease (Mpro) of SARS-COV-2 from crude natural extractsArticle Published on 2023-01-152022-11-15 Journal: Talanta [Category] SARS, 유전자 메커니즘, 치료제, [키워드] Analysis applied approach baicalein binding carried catalytic characteristic Chinese complementary complex Compound Covalent binder Cys145 database drug target electrophilic Final functional HIS163 HIS164 His41 independent inhibitor inhibitors Ion knowledge M pro M(pro) mass mass spectrometry maturation metabolomic metabolomics Michael molecular dynamics MPro nucleophilic peptide platform polyprotein protease protein-ligand Proteins proteomic proteomics residue SARS-CoV-2 SARS-CoV-2. Scutellaria baicalensis tested the SARS-CoV-2 [DOI] 10.1016/j.talanta.2022.123824 PMC 바로가기
Heritability of Protein and Metabolite Biomarkers Associated with COVID-19 Severity: A Metabolomics and Proteomics AnalysisArticle Published on 2022-12-272023-07-11 Journal: Biomolecules [Category] COVID19(2023년), [키워드] Biomarkers COVID-19 erythrocytes metabolomics proteomics. SARS-CoV-2 [DOI] 10.3390/biom13010046 PMC 바로가기
Clinical microbiology in detection and identification of emerging microbial pathogens: past, present and futureArticle Published on 2022-12-012022-11-15 Journal: Emerging Microbes & Infections [Category] 진단, [키워드] Antibody assays Antigen Bacterial pathogens change clinical clinical microbiology Clinical practice COVID-19 COVID-19 pandemic Critical Culture Diagnosis diagnostics Diseases evidenced Genomics Gram stain IMPROVE in vitro Infectious disease metabolomics microbial microbial infections Molecular biology MONITOR morphology nucleic acid nucleic acid amplification outcome pathogen detection Patient point of care progression proteomics Revolutionary transcriptomics transcriptomics. [DOI] 10.1080/22221751.2022.2125345 PMC 바로가기
The role of multi-omics in the diagnosis of COVID-19 and the prediction of new therapeutic targetsReview Published on 2022-12-012023-07-09 Journal: Virulence [Category] COVID19(2023년), [키워드] COVID-19 Genomics metabolomics Multi-omics proteomics transcriptomic. [DOI] 10.1080/21505594.2022.2092941 PMC 바로가기 [Article Type] Review
Saliva metabolomic profile of COVID-19 patients associates with disease severityArticle Published on 2022-10-222022-11-15 Journal: Metabolomics [Category] COVID19(2023년), SARS, 바이오마커, 치료기술, [키워드] 5-aminolevulinic acid Asymptomatic Biomarker Biomarkers C-reactive protein cellular change changes changes in Comparisons controls Coronavirus disease 2019 correlated COVID-19 COVID-19 group COVID-19 patient COVID-19 patients D-dimer diagnostic Disease progression disease severity dysregulation early stage expected Infection intensity Level liquid liquid chromatography-mass spectrometry metabolite metabolomic metabolomics Mild moderate molecular non-infected non-severe patients parameter Patient physiological plasma positively correlated profile prognostic prognostic biomarker risk Saliva Saliva. SARS-CoV-2 screened severity significantly sphingosine stages utility were used [DOI] 10.1007/s11306-022-01936-1 PMC 바로가기
Multi-Omics Reveals Mechanisms of Partial Modulation of COVID-19 Dysregulation by Glucocorticoid TreatmentArticle Published on 2022-10-112022-11-16 Journal: International Journal of Molecular Sciences [Category] 유전자 메커니즘, [키워드] acquisition Amino acid analysed Analysis arginine caused Cohort Concentration COVID-19 COVID-19 infection COVID-19 infections COVID-19 pathogenesis dataset degranulation Dexamethasone dysregulation effective feature glucocorticoid Glucocorticoid treatment Glucocorticoids Guidance highlight include indicated Interaction mass spectrometry metabolomics modulation mortality rates Multi-omics neutrophil oxygen supplementation pandemic Partial participant pathway Pathway analysis Patient Platelet proteomics proteomics. Quantitative serum statistically significant Treatment treatment regimen tyrosine was performed [DOI] 10.3390/ijms232012079 PMC 바로가기
Mask assistance to colorimetric sniffers for detection of Covid-19 disease using exhaled breath metabolitesResearch article Published on 2022-10-012022-10-05 Journal: Sensors and Actuators B: Chemical [Category] 진단, 치료기술, [키워드] Accuracy acute respiratory syndrome approach breath Breath analysis calculated change changes in Colorimetric sniffers Comorbidity Complexes component Compound coronavirus correlation COVID-19 detection cured detect diabete diagnosed diagnostic Diagnostic method died disease effective evaluated Face mask globe Gold nanoparticle healthy Human Interaction introduced kidney linear lung management Mask metabolite metabolomics monitoring Non-invasive methods optical Patient porphyrins rapid test kit responses rRT-PCR SARS-CoV-2 severity smoker the disease unique Viral load World Health Organization [DOI] 10.1016/j.snb.2022.132379 [Article Type] Research article
Highly perturbed genes and hub genes associated with type 2 diabetes in different tissues of adult humans: a bioinformatics analytic workflowArticle Published on 2022-10-012022-11-16 Journal: Functional & integrative genomics [Category] meta-analysis, [키워드] analysis Apoptosis applied approach association bioinformatics cell type complex defined diabete diabetes Differential gene expression differentially expressed gene downregulated downstream analysis eligible etiology FIVE Gene Expression Gene Expression Omnibus Genes Genetic greater Highly perturbed genes hub gene hub genes identify insulin Kyoto Manifestations marker gene Meta-analysis metabolomics Microarray non-specific ontologies Pathogenesis pathophysiological pathway Pathways Perturbation profiles provided random effect significantly systematic review T2D tissue Type type 2 diabete type 2 diabetes. upregulated utility [DOI] 10.1007/s10142-022-00881-5 PMC 바로가기
SARS-CoV-2 infection impacts carbon metabolism and depends on glutamine for replication in Syrian hamster astrocytesArticle Published on 2022-10-012022-11-16 Journal: Journal of neurochemistry [Category] COVID19(2023년), SARS, 치료기술, [키워드] Alpha Alter Astrocyte astrocytes blockade Brain carbon metabolism cause change Cognitive impairment Confusion COVID-19 death evaluated Evidence evidenced Glucose Glutamine Glycolysis hamsters Hyperactivation Immunopathogenesis Impact in vitro in vivo Inflammatory response intranasally ketoglutarate Lung disease memory metabolomics neurological Neurological diseases neurological impairment Neuropathology neurotransmitter olfactory Protein proteomics proteomics. pyruvate reduction Replication SARS-CoV-2 SARS-COV-2 infection SARS-CoV2 synaptic Transmission viral replication [DOI] 10.1111/jnc.15679 PMC 바로가기
Metabolomics-based investigation of SARS-CoV-2 vaccination (Sinovac) reveals an immune-dependent metabolite biomarkerArticle Published on 2022-09-282022-11-15 Journal: Frontiers in Immunology [Category] SARS, 바이오마커, 변종, 진단, [키워드] analyses Analysis antibodies and cytokines antibody association AUC Biomarker boost butanoate collected COVID-19 COVID-19 vaccine Cytokines determine effective fatality FDR Fold change GABA Glutamate greater help Host host immunity IgA IgG IgM immune Immunity IMPROVE individual indole Infection L-glutamic acid metabolism metabolite metabolome metabolomic metabolomic analysis metabolomics mutant strain mutated Pathways positive pre-vaccination provide respond reveal SARS-CoV-2 SARS-CoV-2 vaccination SARS-CoV-2 virus infection sera serum serum antibody serum. Sinovac Spread Taurine vaccination Vaccine VIP Volunteer was performed [DOI] 10.3389/fimmu.2022.954801 PMC 바로가기